Fine Synthetic Nucleoside Chemistry Based on Nucleoside Natural Products Synthesis

Chemical Synthesis of Nucleoside Analogues Chemical Synthesis of Nucleoside Analogues

Multicomponent reactions in nucleoside chemistry

This review covers sixty original publications dealing with the application of multicomponent reactions (MCRs) in the synthesis of novel nucleoside analogs. The reported approaches were employed for modifications of the parent nucleoside core or for de novo construction of a nucleoside scaffold from non-nucleoside substrates. The cited references are grouped according to the usually recognized ...

Synthesis of γ-labeled nucleoside 5'-triphosphates using click chemistry.

Real-time enzymatic studies are gaining importance as their chemical and technical instrumentation improves. Here we report the efficient synthesis of γ-alkyne modified triphosphate amidates that are converted into a variety of γ-fluorophore labeled triphosphates by Cu(I) catalyzed alkyne/azide click reactions. The synthesized triphosphates are incorporated into DNA by DNA polymerases.

[Synthetic study of nucleoside antibiotics].

Some of nucleoside antibiotics include complex structures as well as sensitive functionality, which are challenging targets for organic chemists. Among complex nucleoside antibiotics, there are also good drug candidates because they possess a variety of interesting biological properties. Herbicidin B and fully protected tunicaminyluracil, which were undecose nucleoside antibiotics, were synthes...

Nucleoside Analogues. Chemistry, Biology, and Medical Applications

This large volume records the proceedings of an International Symposium on the structure of Gangliosides held in France in 1979. The list of participants is composed of many leaders in this branch of neurochemistry. Divided into six sections, the book addresses the chemistry, biochemistry, identification, metabolism, and function of gangliosides. Methodologic data including NMR spectra, high re...